ReDisulphID

a tool for identifying drug-targetable redox-active disulphides

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Cytochrome c isoform 1

Intermolecular
Cysteine 23 and cysteine 104 of Adrenodoxin, mitochondrial
Cysteine 23 and cysteine 110 of Adrenodoxin, mitochondrial
A redox-regulated disulphide may form between cysteine 23 of Cytochrome c isoform 1 and cysteine 104 of Adrenodoxin, mitochondrial (17 and 46 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
45
PDB code
2jqr
Structure name
solution model of crosslinked complex of cytochrome c and adrenodoxin
Structure deposition date
2007-06-07
Thiol separation (Å)
10
Half-sphere exposure sum ?
57
Minimum pKa ?
7
% buried
61
Peptide A name
Cytochrome c isoform 1
Peptide B name
Adrenodoxin, mitochondrial
Peptide A accession
P00044
Peptide B accession
P00257
Peptide A residue number
23
Peptide B residue number
104

Ligandability

Cysteine 23 of Cytochrome c isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 104 of Adrenodoxin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

A redox-regulated disulphide may form between cysteine 23 of Cytochrome c isoform 1 and cysteine 110 of Adrenodoxin, mitochondrial (17 and 52 respectively in this structure). However, the redox score of this cysteine pair is lower than any known redox-active intermolecular disulphide. ?

Details

Redox score ?
41
PDB code
2jqr
Structure name
solution model of crosslinked complex of cytochrome c and adrenodoxin
Structure deposition date
2007-06-07
Thiol separation (Å)
8
Half-sphere exposure sum ?
72
Minimum pKa ?
11
% buried
74
Peptide A name
Cytochrome c isoform 1
Peptide B name
Adrenodoxin, mitochondrial
Peptide A accession
P00044
Peptide B accession
P00257
Peptide A residue number
23
Peptide B residue number
110

Ligandability

Cysteine 23 of Cytochrome c isoform 1

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

Cysteine 110 of Adrenodoxin, mitochondrial

Not ligandable in the dataset of Yang et al.

Not ligandable in the dataset of Yan et al.

Not ligandable in the dataset of Backus et al.

Not ligandable in the dataset of Vinogradova et al.

Not ligandable in the dataset of Cao et al.

Not ligandable in the dataset of Kuljanin et al.

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